Hyperbaric Oxygen ( HBO) therapy is a method of increasing oxygen delivery to tissues. Tissue oxygenation is an important part of the complex regulation for wound healing. Wound healing is a physiological process that occurs progressively through overlapping phases. Susilo, Imam Devi, Anita Purwandhono, Azham Hadi Warsito, Sunaryo
HBO does not immediately affect cerebral oxygen metabolism, and the underlying mechanism still needs to be studied in depth.Įffects of hyperbaric oxygen therapy in enhancing expressions of e-NOS, TNF-α and VEGF in wound healing Our findings suggest that there is a disorder of oxygen metabolism in patients with sub-acute TBI. PaO 2 levels were significantly decreased after the 30-minute HBO treatment. rSO 2 levels in the patients did not differ significantly after treatment, but levels before and after treatment were significantly lower than those in the control group. The controls were also examined for rSO 2 and PaO 2, but received no treatment. The 40 patients were given 100% oxygen of HBO for 90 minutes. To test this idea, we compared two groups: a control group with 20 healthy people and a treatment group with 40 TBI patients. We hypothesized that hyperbaric oxygen treatment plays a neuroprotective role in TBI by increasing regional transcranial oxygen saturation (rSO 2 ) and oxygen partial pressure (PaO 2 ). Neuroprotection of hyperbaric oxygen therapy in sub-acute traumatic brain injury: not by immediately improving cerebral oxygen saturation and oxygen partial pressure.Īlthough hyperbaric oxygen ( HBO) therapy can promote the recovery of neural function in patients who have suffered traumatic brain injury (TBI), the underlying mechanism is unclear. The experiment demonstrated the effectiveness of HBO + LEDtherapy treatment by favoring the ulcer healing through an increased fibroblastic response, collagen synthesis and neo-vascularization of the ischaemia, as well as increases in the leukocytic bactericidal activity. During the experiment nine patients with diabetic foot ulcers were submitted for HBO sessions with 2,5 ATM for two hours. The LEDtherapy irradiation was given concurrently using an energy density of 4J/cm2 for 5 min. In ulcers of diabetic foot these treatments lead to a reduction in the probability of amputation up to almost four times compared with patients not receiving such co-adjutant treatment.
In this work it was evaluated the effects of adjunctive Hyperbaric Oxygen Therapy ( HBO) treatment and LEDtherapy irradiation on ulcer healing ( HBO) in addition to conventional treatment. Carvalho, Marcos V.Ĭhronic foot ulcers are common ailments presented in diabetes, which offer severe complications and are often unresponsive to therapy. The use of hyperbaric oxygen therapy and LED therapy in diabetic foot
More translational studies and clinical trials are needed in the future to develop effective HBO protocols. Nevertheless, the lack of clinical translational study limits the application of HBO. Actually, accumulated basic and clinical evidences have demonstrated that HBO therapy and preconditioning could induce neuroprotective functions via different mechanisms. Hence, HBO possesses the potentials to produce beneficial effects on stroke. Hyperbaric oxygen ( HBO), an approach through a process in which patients breathe in 100% pure oxygen at over 101 kPa, has been shown to facilitate oxygen delivery and increase oxygen supply. The lack of oxygen supply is critical for brain injury following stroke. To date, the therapeutic methods for ischemic and hemorrhagic stroke are still limited. Hyperbaric oxygen therapy and preconditioning for ischemic and hemorrhagic stroke.
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